A popular cross-platform Python GUI toolkit for Windows and Unix with native look and feel on each platform. [Open Source, LGPL]

A software construction kit built in, and using, Python. Its purpose is to allow you to easily and quickly build graphical applications. [Open Source, Python license]

Contains Python bindings for the Qt GUI toolkit. [Open Source, BSD-like]

The Tk Interface eXtension is a set of GUI components that enhance the appearance and functionality of your Tkinter applications. [Open Source, BSD-like]

Python meta widgets is a toolkit for building high-level compound widgets in Python using the Tkinter module. [Open Source, MIT license]

Tkinter3000 is a Widget Construction Kit that allows you to write new Tkinter widgets in Python using Mixins. [Open Source, BSD-like]

Provides an interface to the FOX GUI library. [Open Source, LGPL]

A set of Python extension modules designed for writing games. The core of pygame is wrapped on top of the SDL library. [Open Source, LGPL]

Pure Python interface to X Window system. [Open Source, GPL]

A 3-tier, cross-platform application development framework, written in Python atop the wxPython GUI toolkit. [Open source, MIT license]