An enhanced interactive Python shell with many features for object introspection, system shell access, and its own special command system for adding functionality when working interactively. [Open Source, LGPL] http://ipython.scipy.org/
A tool intended to generate a python object model, relational database, and an object-relational model connecting the two using UML or XML. However, it has been extended to also output GUI widgets and can be easily extended to output whatever else you mig http://pymerase.sourceforge.net/
An advanced python debugger, with support for smart breakpoints, multiple threads, namespace modification, embedded debugging and encrypted communication. http://www.digitalpeers.com/pythondebugger/
Tixapps applications are a suite of development applications that run with Tk/Tcl or Python, using the Tix widget set. [Open Source, BSD-like] http://tix.sourceforge.net/Tixapps/